6WO4

Structure of Hepatitis C Virus Envelope Glycoprotein E2 core from genotype 6a bound to broadly neutralizing antibody HC11

Summary for 6WO4

Entry DOI	10.2210/pdb6wo4/pdb
Descriptor	Fab HC11 heavy chain, Envelope glycoprotein E2, Fab HC11 light chain, ... (6 entities in total)
Functional Keywords	hcv, broadly neutralizing antibodies, bnabs, e2 core, ighv1-69, immune system
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	71593.33
Authors	Tzarum, N.,Wilson, I.A.,Law, M. (deposition date: 2020-04-24, release date: 2020-08-19, Last modification date: 2023-10-18)
Primary citation	Tzarum, N.,Giang, E.,Kadam, R.U.,Chen, F.,Nagy, K.,Augestad, E.H.,Velazquez-Moctezuma, R.,Keck, Z.Y.,Hua, Y.,Stanfield, R.L.,Dreux, M.,Prentoe, J.,Foung, S.K.H.,Bukh, J.,Wilson, I.A.,Law, M. An alternate conformation of HCV E2 neutralizing face as an additional vaccine target. Sci Adv, 6:eabb5642-eabb5642, 2020 Cited by PubMed: 32754640 DOI: 10.1126/sciadv.abb5642 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.349 Å)

Structure validation