6WNH

Menin bound to inhibitor M-808

Summary for 6WNH

Entry DOI	10.2210/pdb6wnh/pdb
Descriptor	Menin, methyl [(1S,2R)-2-{(1S)-2-(azetidin-1-yl)-1-(3-fluorophenyl)-1-[1-({1-[4-({1-[4-(piperidin-1-yl)butanoyl]azetidin-3-yl}sulfonyl)phenyl]azetidin-3-yl}methyl)piperidin-4-yl]ethyl}cyclopentyl]carbamate, praseodymium triacetate, ... (4 entities in total)
Functional Keywords	inhibitor, protein binding, transcription
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	63472.53
Authors	Stuckey, J.A. (deposition date: 2020-04-22, release date: 2020-05-13, Last modification date: 2023-10-18)
Primary citation	Xu, S.,Aguilar, A.,Huang, L.,Xu, T.,Zheng, K.,McEachern, D.,Przybranowski, S.,Foster, C.,Zawacki, K.,Liu, Z.,Chinnaswamy, K.,Stuckey, J.,Wang, S. Discovery of M-808 as a Highly Potent, Covalent, Small-Molecule Inhibitor of the Menin-MLL Interaction with StrongIn VivoAntitumor Activity. J.Med.Chem., 63:4997-5010, 2020 Cited by PubMed: 32338903 DOI: 10.1021/acs.jmedchem.0c00547 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation