6WJ7

The structure of NTMT1 in complex with compound C2A

Summary for 6WJ7

• Entry DOI: 10.2210/pdb6wj7/pdb
• Descriptor: N-terminal Xaa-Pro-Lys N-methyltransferase 1, GLY-PRO-LYS-ARG-ILE-ALA-NH2, 5'-{[(3S)-3-amino-3-carboxypropyl](ethyl)amino}-5'-deoxyadenosine, ... (4 entities in total)
• Functional Keywords: methyltransferase, enzyme, inhibitor complex, transferase, transferase-transferase-inhibitor complex
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 28356.29

Authors

Srinivasan, K.,Chen, D.,Huang, R.,Noinaj, N. (deposition date: 2020-04-13, release date: 2020-08-19, Last modification date: 2024-04-24)

• Primary citation: Chen, D.,Dong, C.,Dong, G.,Srinivasan, K.,Min, J.,Noinaj, N.,Huang, R.; Probing the Plasticity in the Active Site of Protein N-terminal Methyltransferase 1 Using Bisubstrate Analogues.; J.Med.Chem., 63:8419-8431, 2020; PubMed: 32605369; DOI: 10.1021/acs.jmedchem.0c00770

Experimental method

X-RAY DIFFRACTION (1.42 Å)