6WIV

Structure of human GABA(B) receptor in an inactive state

Summary for 6WIV

• Entry DOI: 10.2210/pdb6wiv/pdb
• EMDB information: 21685
• Descriptor: Gamma-aminobutyric acid type B receptor subunit 1, Gamma-aminobutyric acid type B receptor subunit 2, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: g protein coupled receptor (gpcr), gaba, gaba(b) receptor, class c gpcr, phospholipids, inhibitory neurotransmission., membrane protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 191236.30

Authors

Park, J.,Fu, Z.,Frangaj, A.,Liu, J.,Mosyak, L.,Shen, T.,Slavkovich, V.N.,Ray, K.M.,Taura, J.,Cao, B.,Geng, Y.,Zuo, H.,Kou, Y.,Grassucci, R.,Chen, S.,Liu, Z.,Lin, X.,Williams, J.P.,Rice, W.J.,Eng, E.T.,Huang, R.K.,Soni, R.K.,Kloss, B.,Yu, Z.,Javitch, J.A.,Hendrickson, W.A.,Slesinger, P.A.,Quick, M.,Graziano, J.,Yu, H.,Fiehn, O.,Clarke, O.B.,Frank, J.,Fan, Q.R. (deposition date: 2020-04-10, release date: 2020-07-01, Last modification date: 2020-08-26)

• Primary citation: Park, J.,Fu, Z.,Frangaj, A.,Liu, J.,Mosyak, L.,Shen, T.,Slavkovich, V.N.,Ray, K.M.,Taura, J.,Cao, B.,Geng, Y.,Zuo, H.,Kou, Y.,Grassucci, R.,Chen, S.,Liu, Z.,Lin, X.,Williams, J.P.,Rice, W.J.,Eng, E.T.,Huang, R.K.,Soni, R.K.,Kloss, B.,Yu, Z.,Javitch, J.A.,Hendrickson, W.A.,Slesinger, P.A.,Quick, M.,Graziano, J.,Yu, H.,Fiehn, O.,Clarke, O.B.,Frank, J.,Fan, Q.R.; Structure of human GABABreceptor in an inactive state.; Nature, 584:304-309, 2020; PubMed: 32581365; DOI: 10.1038/s41586-020-2452-0

Experimental method

ELECTRON MICROSCOPY (3.3 Å)