6WII

Crystal structure of the K. pneumoniae LpxH/JH-LPH-41 complex

Summary for 6WII

Entry DOI	10.2210/pdb6wii/pdb
Descriptor	UDP-2,3-diacylglucosamine hydrolase, 5-({[4-({4-[3-chloro-5-(trifluoromethyl)phenyl]piperazin-1-yl}sulfonyl)phenyl]carbamoyl}amino)-N-hydroxypentanamide, MANGANESE (II) ION, ... (6 entities in total)
Functional Keywords	lpxh, jh-lph-41, lipid a, antibiotic, hydrolase
Biological source	Klebsiella pneumoniae
Total number of polymer chains	1
Total formula weight	30642.05
Authors	Cochrane, C.S.,Cho, J.,Fenton, B.A.,Zhou, P. (deposition date: 2020-04-09, release date: 2020-07-29, Last modification date: 2023-10-18)
Primary citation	Kwak, S.H.,Cochrane, C.S.,Ennis, A.F.,Lim, W.Y.,Webster, C.G.,Cho, J.,Fenton, B.A.,Zhou, P.,Hong, J. Synthesis and evaluation of sulfonyl piperazine LpxH inhibitors. Bioorg.Chem., 102:104055-104055, 2020 Cited by PubMed: 32663666 DOI: 10.1016/j.bioorg.2020.104055 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.85 Å)

Structure validation