6WDX

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Hydroxyethylindole Phenylhydroxamate Inhibitor

Summary for 6WDX

Entry DOI	10.2210/pdb6wdx/pdb
Descriptor	Polyamine deacetylase HDAC10, N-hydroxy-4-{[3-(2-hydroxyethyl)-1H-indol-1-yl]methyl}benzamide, ZINC ION, ... (6 entities in total)
Functional Keywords	histone deacetylase, hydolase-hydrolase inhibitor complex, hydolase/hydrolase inhibitor
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	75794.51
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2020-04-01, release date: 2020-07-22, Last modification date: 2023-10-18)
Primary citation	Herbst-Gervasoni, C.J.,Steimbach, R.R.,Morgen, M.,Miller, A.K.,Christianson, D.W. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chem.Biol., 15:2154-2163, 2020 Cited by PubMed: 32659072 DOI: 10.1021/acschembio.0c00362 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.65 Å)

Structure validation