6WCZ
CryoEM structure of full-length ZIKV NS5-hSTAT2 complex
Summary for 6WCZ
Entry DOI | 10.2210/pdb6wcz/pdb |
EMDB information | 21618 |
Descriptor | Signal transducer and activator of transcription 2, Non-structural protein 5, ZINC ION (3 entities in total) |
Functional Keywords | zikv ns5, hstat2, cryoem, immune system |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 2 |
Total formula weight | 201274.55 |
Authors | Boxiao, W.,Stephanie, T.,Kang, Z.,Maria, T.S.,Jian, F.,Jiuwei, L.,Linfeng, G.,Wendan, R.,Yanxiang, C.,Ethan, C.V.,HeaJin, H.,Matthew, J.E.,Sean, E.O.,Adolfo, G.S.,Hong, Z.,Rong, H.,Jikui, S. (deposition date: 2020-03-31, release date: 2020-07-08, Last modification date: 2021-08-25) |
Primary citation | Wang, B.,Thurmond, S.,Zhou, K.,Sanchez-Aparicio, M.T.,Fang, J.,Lu, J.,Gao, L.,Ren, W.,Cui, Y.,Veit, E.C.,Hong, H.,Evans, M.J.,O'Leary, S.E.,Garcia-Sastre, A.,Zhou, Z.H.,Hai, R.,Song, J. Structural basis for STAT2 suppression by flavivirus NS5. Nat.Struct.Mol.Biol., 27:875-885, 2020 Cited by PubMed: 32778820DOI: 10.1038/s41594-020-0472-y PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (4 Å) |
Structure validation
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