6WC5

Crystal Structure of a Ternary MEF2B/NKX2-5/myocardin enhancer DNA Complex

Summary for 6WC5

• Entry DOI: 10.2210/pdb6wc5/pdb
• Descriptor: Myocyte-specific enhancer factor 2B, Myocardin enhancer DNA, Homeobox protein Nkx-2.5, ... (5 entities in total)
• Functional Keywords: transcription complex, cardiogenesis, carcinogenesis, mads-box and homeobox, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 10
• Total formula weight: 84035.68

Authors

Chen, L.,Lei, X. (deposition date: 2020-03-29, release date: 2020-07-22, Last modification date: 2023-10-18)

• Primary citation: Lei, X.,Zhao, J.,Sagendorf, J.M.,Rajashekar, N.,Xu, J.,Dantas Machado, A.C.,Sen, C.,Rohs, R.,Feng, P.,Chen, L.; Crystal Structures of Ternary Complexes of MEF2 and NKX2-5 Bound to DNA Reveal a Disease Related Protein-Protein Interaction Interface.; J.Mol.Biol., 432:5499-5508, 2020; PubMed: 32681840; DOI: 10.1016/j.jmb.2020.07.004

Experimental method

X-RAY DIFFRACTION (2.9 Å)