6WBQ

Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with Tubastatin A

Summary for 6WBQ

Entry DOI	10.2210/pdb6wbq/pdb
Descriptor	Polyamine deacetylase HDAC10, 4-[(2-methyl-3,4-dihydro-1~{H}-pyrido[4,3-b]indol-5-yl)methyl]-~{N}-oxidanyl-benzamide, 1,2-ETHANEDIOL, ... (7 entities in total)
Functional Keywords	histone deacetylase, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	76129.90
Authors	Herbst-Gervasoni, C.J.,Christianson, D.W. (deposition date: 2020-03-27, release date: 2020-07-22, Last modification date: 2023-10-18)
Primary citation	Herbst-Gervasoni, C.J.,Steimbach, R.R.,Morgen, M.,Miller, A.K.,Christianson, D.W. Structural Basis for the Selective Inhibition of HDAC10, the Cytosolic Polyamine Deacetylase. Acs Chem.Biol., 15:2154-2163, 2020 Cited by PubMed: 32659072 DOI: 10.1021/acschembio.0c00362 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation