6W4T

APE1 Y269A phosphorothioate substrate complex with abasic DNA

Summary for 6W4T

• Entry DOI: 10.2210/pdb6w4t/pdb
• Descriptor: DNA-(apurinic or apyrimidinic site) lyase, DNA (5'-D(P*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*(48Z)P*CP*GP*AP*CP*GP*GP*AP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*TP*CP*CP*GP*TP*CP*GP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... (4 entities in total)
• Functional Keywords: dna repair, ap-endonuclease, dna binding, dna binding protein, dna binding protein-dna complex, lyase-dna complex, lyase/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 87721.33

Authors

Freudenthal, B.D.,Hoitsma, N.M. (deposition date: 2020-03-11, release date: 2020-06-17, Last modification date: 2023-10-18)

• Primary citation: Hoitsma, N.M.,Whitaker, A.M.,Beckwitt, E.C.,Jang, S.,Agarwal, P.K.,Van Houten, B.,Freudenthal, B.D.; AP-endonuclease 1 sculpts DNA through an anchoring tyrosine residue on the DNA intercalating loop.; Nucleic Acids Res., 48:7345-7355, 2020; PubMed: 32542366; DOI: 10.1093/nar/gkaa496

Experimental method

X-RAY DIFFRACTION (2.77 Å)