6W09

Human mAbs broadly protect against infection of arthritiogenic alphaviruses by recognizing conserved elements of the MXR8 receptor binding domain

Summary for 6W09

• Entry DOI: 10.2210/pdb6w09/pdb
• EMDB information: 21496
• Descriptor: E1 glycoprotein, E2 glycoprotein, Fab CHK-265 heavy chain, ... (5 entities in total)
• Functional Keywords: virus, monoclonal antibody, complex, virus-immune system complex, virus/immune system
• Biological source: Chikungunya virus (CHIKV); More
• Total number of polymer chains: 20
• Total formula weight: 538094.70

Authors

Miller, A.S.,Kuhn, R.J. (deposition date: 2020-02-29, release date: 2020-08-26, Last modification date: 2024-03-06)

• Primary citation: Powell, L.A.,Miller, A.,Fox, J.M.,Kose, N.,Klose, T.,Kim, A.S.,Bombardi, R.,Tennekoon, R.N.,Dharshan de Silva, A.,Carnahan, R.H.,Diamond, M.S.,Rossmann, M.G.,Kuhn, R.J.,Crowe Jr., J.E.; Human mAbs Broadly Protect against Arthritogenic Alphaviruses by Recognizing Conserved Elements of the Mxra8 Receptor-Binding Site.; Cell Host Microbe, 28:699-711.e7, 2020; PubMed: 32783883; DOI: 10.1016/j.chom.2020.07.008

Experimental method

ELECTRON MICROSCOPY (5.3 Å)