6VXG

Structure of the C-terminal Domain of RAGE and Its Inhibitor

Summary for 6VXG

• Entry DOI: 10.2210/pdb6vxg/pdb
• Related: 2LMB
• NMR Information: BMRB: 30726
• Descriptor: Advanced glycosylation end product-specific receptor, N-(4-{7-cyano-4-[(morpholin-4-yl)methyl]quinolin-2-yl}phenyl)acetamide (2 entities in total)
• Functional Keywords: inhibitor, complex, diabetes, receptor for advanced glycated end products, inflammation, signaling protein, signaling protein-inhibitor complex, signaling protein/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 5421.69

Authors

Ramirez, L.,Shekhtman, A. (deposition date: 2020-02-21, release date: 2021-02-24, Last modification date: 2022-03-09)

• Primary citation: Manigrasso, M.B.,Rabbani, P.,Egana-Gorrono, L.,Quadri, N.,Frye, L.,Zhou, B.,Reverdatto, S.,Ramirez, L.S.,Dansereau, S.,Pan, J.,Li, H.,D'Agati, V.D.,Ramasamy, R.,DeVita, R.J.,Shekhtman, A.,Schmidt, A.M.; Small-molecule antagonism of the interaction of the RAGE cytoplasmic domain with DIAPH1 reduces diabetic complications in mice.; Sci Transl Med, 13:eabf7084-eabf7084, 2021; PubMed: 34818060; DOI: 10.1126/scitranslmed.abf7084

Experimental method

SOLUTION NMR