6VW2

Cryo-EM structure of human islet amyloid polypeptide (hIAPP, or amylin) fibrils

Summary for 6VW2

• Entry DOI: 10.2210/pdb6vw2/pdb
• EMDB information: 21410
• Descriptor: Islet amyloid polypeptide (SUMO-tagged) (1 entity in total)
• Functional Keywords: hiapp, type ii diabetes, amyloid, protein fibril
• Biological source: Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast); More
• Total number of polymer chains: 10
• Total formula weight: 172742.73

Authors

Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Eisenberg, D.S. (deposition date: 2020-02-18, release date: 2020-06-10, Last modification date: 2024-03-06)

• Primary citation: Cao, Q.,Boyer, D.R.,Sawaya, M.R.,Ge, P.,Eisenberg, D.S.; Cryo-EM structure and inhibitor design of human IAPP (amylin) fibrils.; Nat.Struct.Mol.Biol., 27:653-659, 2020; PubMed: 32541896; DOI: 10.1038/s41594-020-0435-3

Experimental method

ELECTRON MICROSCOPY (3.4 Å)