6VTX

Crystal structure of human KLF4 zinc finger DNA binding domain in complex with NANOG DNA

Summary for 6VTX

• Entry DOI: 10.2210/pdb6vtx/pdb
• Descriptor: Krueppel-like factor 4, DNA (5'-D(*AP*GP*GP*GP*GP*GP*TP*GP*TP*GP*CP*C)-3'), DNA (5'-D(*GP*GP*CP*AP*CP*AP*CP*CP*CP*CP*CP*T)-3'), ... (6 entities in total)
• Functional Keywords: klf4, zinc finger, dna binding domain, dna binding protein, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 17545.31

Authors

Sharma, R.,Sharma, S.,Choi, K.J.,Ferreon, A.C.M.,Ferreon, J.C.,Sankaran, B.,MacKenzie, K.R.,Kim, C. (deposition date: 2020-02-13, release date: 2021-09-01, Last modification date: 2023-10-11)

• Primary citation: Sharma, R.,Choi, K.J.,Quan, M.D.,Sharma, S.,Sankaran, B.,Park, H.,LaGrone, A.,Kim, J.J.,MacKenzie, K.R.,Ferreon, A.C.M.,Kim, C.,Ferreon, J.C.; Liquid condensation of reprogramming factor KLF4 with DNA provides a mechanism for chromatin organization.; Nat Commun, 12:5579-5579, 2021; PubMed: 34552088; DOI: 10.1038/s41467-021-25761-7

Experimental method

X-RAY DIFFRACTION (2.14 Å)