6VND

Quaternary Complex of human dihydroorotate dehydrogenase (DHODH) with flavin mononucleotide (FMN), orotic acid and AG-636

Summary for 6VND

• Entry DOI: 10.2210/pdb6vnd/pdb
• Descriptor: Dihydroorotate dehydrogenase (quinone), mitochondrial, GLYCEROL, 1-methyl-5-(2'-methyl[1,1'-biphenyl]-4-yl)-1H-benzotriazole-7-carboxylic acid, ... (11 entities in total)
• Functional Keywords: dhodh, oxidoreductase, fmn binding, inhibitor, mitochondria inner membrane, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 42536.97

Authors

Padyana, A.,Jin, L. (deposition date: 2020-01-29, release date: 2020-11-04, Last modification date: 2023-10-11)

• Primary citation: McDonald, G.,Chubukov, V.,Coco, J.,Truskowski, K.,Narayanaswamy, R.,Choe, S.,Steadman, M.,Artin, E.,Padyana, A.K.,Jin, L.,Ronseaux, S.,Locuson, C.,Fan, Z.P.,Erdmann, T.,Mann, A.,Hayes, S.,Fletcher, M.,Nellore, K.,Rao, S.S.,Subramanya, H.,Reddy, K.S.,Panigrahi, S.K.,Antony, T.,Gopinath, S.,Sui, Z.,Nagaraja, N.,Dang, L.,Lenz, G.,Hurov, J.,Biller, S.A.,Murtie, J.,Marks, K.M.,Ulanet, D.B.; Selective Vulnerability to Pyrimidine Starvation in Hematologic Malignancies Revealed by AG-636, a Novel Clinical-Stage Inhibitor of Dihydroorotate Dehydrogenase.; Mol.Cancer Ther., 19:2502-2515, 2020; PubMed: 33082276; DOI: 10.1158/1535-7163.MCT-20-0550

Experimental method

X-RAY DIFFRACTION (1.97 Å)