6VN2

USP7 IN COMPLEX WITH LIGAND COMPOUND 18

Summary for 6VN2

• Entry DOI: 10.2210/pdb6vn2/pdb
• Descriptor: Ubiquitin carboxyl-terminal hydrolase 7, 1-({7-[(2R)-5-chloro-2-(piperazine-1-carbonyl)-2,3-dihydro-1-benzofuran-7-yl]thieno[3,2-b]pyridin-2-yl}methyl)-1H-pyrrole-2,5-dione, ACETATE ION, ... (4 entities in total)
• Functional Keywords: usp7, dub, deubiquitinase, hydrolase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 82032.51

Authors

Leger, P.R.,Wustrow, D.J.,Hu, D.X.,Krapp, S.,Maskos, K.,Blaesse, M. (deposition date: 2020-01-29, release date: 2020-04-29, Last modification date: 2020-06-17)

• Primary citation: Leger, P.R.,Hu, D.X.,Biannic, B.,Bui, M.,Han, X.,Karbarz, E.,Maung, J.,Okano, A.,Osipov, M.,Shibuya, G.M.,Young, K.,Higgs, C.,Abraham, B.,Bradford, D.,Cho, C.,Colas, C.,Jacobson, S.,Ohol, Y.M.,Pookot, D.,Rana, P.,Sanchez, J.,Shah, N.,Sun, M.,Wong, S.,Brockstedt, D.G.,Kassner, P.D.,Schwarz, J.B.,Wustrow, D.J.; Discovery of Potent, Selective, and Orally Bioavailable Inhibitors of USP7 with In Vivo Antitumor Activity.; J.Med.Chem., 63:5398-5420, 2020; PubMed: 32302140; DOI: 10.1021/acs.jmedchem.0c00245

Experimental method

X-RAY DIFFRACTION (2.93 Å)