6VJE

Crystal structure of Pseudomonas aeruginosa penicillin-binding protein 3 (PBP3) complexed with ceftobiprole

Summary for 6VJE

Entry DOI	10.2210/pdb6vje/pdb
Descriptor	Peptidoglycan D,D-transpeptidase FtsI, (2R)-2-[(1R)-1-{[(2Z)-2-(5-amino-1,2,4-thiadiazol-3-yl)-2-(hydroxyimino)acetyl]amino}-2-oxoethyl]-5-({2-oxo-1-[(3R)-pyr rolidin-3-yl]-2,5-dihydro-1H-pyrrol-3-yl}methyl)-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	antibiotic target, complex, hydrolase
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	58936.94
Authors	van den Akker, F.,Kumar, V. (deposition date: 2020-01-15, release date: 2020-03-11, Last modification date: 2023-10-11)
Primary citation	Kumar, V.,Tang, C.,Bethel, C.R.,Papp-Wallace, K.M.,Wyatt, J.,Desarbre, E.,Bonomo, R.A.,van den Akker, F. Structural Insights into Ceftobiprole Inhibition of Pseudomonas aeruginosa Penicillin-Binding Protein 3. Antimicrob.Agents Chemother., 64:-, 2020 Cited by PubMed: 32152075 DOI: 10.1128/AAC.00106-20 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.76 Å)

Structure validation