6VIF

Human LRH-1 ligand-binding domain bound to agonist cpd 15 and fragment of coregulator TIF-2

Summary for 6VIF

• Entry DOI: 10.2210/pdb6vif/pdb
• Descriptor: Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, N-[(8beta,11alpha,12alpha)-8-{[methyl(phenyl)amino]methyl}-1,6:7,14-dicycloprosta-1(6),2,4,7(14)-tetraen-11-yl]sulfuric diamide, ... (4 entities in total)
• Functional Keywords: ligand-binding domain, nuclear receptor, small molecule, agonist, nuclear protein, liver receptor homolog-1
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 2
• Total formula weight: 30521.32

Authors

Cato, M.L.,Ortlund, E.A. (deposition date: 2020-01-13, release date: 2020-06-10, Last modification date: 2023-10-11)

• Primary citation: Cornelison, J.L.,Cato, M.L.,Johnson, A.M.,D'Agostino, E.H.,Melchers, D.,Patel, A.B.,Mays, S.G.,Houtman, R.,Ortlund, E.A.,Jui, N.T.; Development of a new class of liver receptor homolog-1 (LRH-1) agonists by photoredox conjugate addition.; Bioorg.Med.Chem.Lett., 30:127293-127293, 2020; PubMed: 32631515; DOI: 10.1016/j.bmcl.2020.127293

Experimental method

X-RAY DIFFRACTION (2.26 Å)