6VHW

Klebsiella oxytoca NpsA N-terminal subdomain in complex with 3-hydroxybenzoyl-AMSN

Summary for 6VHW

• Entry DOI: 10.2210/pdb6vhw/pdb
• Descriptor: NpsA Adenylation Domain, 5'-deoxy-5'-{[(3-hydroxybenzene-1-carbonyl)sulfamoyl]amino}adenosine, TRIETHYLENE GLYCOL, ... (8 entities in total)
• Functional Keywords: adenylation, tilivalline, tilimycin, nrps, nonribosomal peptide synthetase, biosynthetic protein
• Biological source: Klebsiella oxytoca
• Total number of polymer chains: 2
• Total formula weight: 89833.83

Authors

Kreitler, D.F.,Gulick, A.M. (deposition date: 2020-01-10, release date: 2020-06-24, Last modification date: 2023-10-11)

• Primary citation: Alexander, E.M.,Kreitler, D.F.,Guidolin, V.,Hurben, A.K.,Drake, E.,Villalta, P.W.,Balbo, S.,Gulick, A.M.,Aldrich, C.C.; Biosynthesis, Mechanism of Action, and Inhibition of the Enterotoxin Tilimycin Produced by the Opportunistic PathogenKlebsiella oxytoca.; Acs Infect Dis., 6:1976-1997, 2020; PubMed: 32485104; DOI: 10.1021/acsinfecdis.0c00326

Experimental method

X-RAY DIFFRACTION (1.83 Å)