6VGD

Crystal structure of the DNA binding domain (DBD) of human FLI1 and the complex of the DBD of human Runx2 with core binding factor beta (Cbfb), in complex with 16mer DNA CAGAGGATGTGGCTTC

Summary for 6VGD

• Entry DOI: 10.2210/pdb6vgd/pdb
• Descriptor: Friend leukemia integration 1 transcription factor, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... (5 entities in total)
• Functional Keywords: ewing sarcoma, enhancer, transcription factor, oncogenesis, prostate cancer, ets-family, runt-family, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 5
• Total formula weight: 59701.55

Authors

Hou, C.,Tsodikov, O.V. (deposition date: 2020-01-07, release date: 2020-11-25, Last modification date: 2023-10-11)

• Primary citation: Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V.; Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.; Structure, 29:404-412.e4, 2021; PubMed: 33275876; DOI: 10.1016/j.str.2020.11.012

Experimental method

X-RAY DIFFRACTION (4.2 Å)