6VG8

Crystal structure of the DNA binding domains of human FLI1 and Runx2 in complex with 16-mer DNA CAGAGGATGTGGCTTC

Summary for 6VG8

• Entry DOI: 10.2210/pdb6vg8/pdb
• Descriptor: Friend leukemia integration 1 transcription factor, DNA (5'-D(P*CP*AP*GP*AP*GP*GP*AP*TP*GP*TP*GP*GP*CP*TP*TP*C)-3'), DNA (5'-D(P*GP*AP*AP*GP*CP*CP*AP*CP*AP*TP*CP*CP*TP*CP*TP*G)-3'), ... (4 entities in total)
• Functional Keywords: oncogenesis, ewing sarcoma, enhancer, bone cancer, leukemia, ets-family, runt-family, transcription
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 4
• Total formula weight: 35597.69

Authors

Hou, C.,Tsodikov, O.V. (deposition date: 2020-01-07, release date: 2020-11-25, Last modification date: 2023-10-11)

• Primary citation: Hou, C.,Mandal, A.,Rohr, J.,Tsodikov, O.V.; Allosteric interference in oncogenic FLI1 and ERG transactions by mithramycins.; Structure, 29:404-412.e4, 2021; PubMed: 33275876; DOI: 10.1016/j.str.2020.11.012

Experimental method

X-RAY DIFFRACTION (4.31 Å)