6V8B

Crystal structure of the p300 acetyltransferase domain with AcCoA competitive inhibitor 1

Summary for 6V8B

Entry DOI	10.2210/pdb6v8b/pdb
Descriptor	Histone acetyltransferase p300, 4-(2-{[(1R)-2-(1H-indol-3-yl)-2-oxo-1-phenylethyl]amino}ethyl)benzene-1-sulfonamide, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	epigenetics, chromatin, writer, transferase, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40964.67
Authors	Gardberg, A.S. (deposition date: 2019-12-10, release date: 2020-04-01, Last modification date: 2024-04-03)
Primary citation	Huhn, A.J.,Gardberg, A.S.,Poy, F.,Brucelle, F.,Vivat, V.,Cantone, N.,Patel, G.,Patel, C.,Cummings, R.,Sims, R.,Levell, J.,Audia, J.E.,Bommi-Reddy, A.,Wilson, J.E. Early Drug-Discovery Efforts towards the Identification of EP300/CBP Histone Acetyltransferase (HAT) Inhibitors. Chemmedchem, 15:955-960, 2020 Cited by PubMed: 32181984 DOI: 10.1002/cmdc.202000007 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.13 Å)

Structure validation