6V5B

Human Drosha and DGCR8 in complex with Primary MicroRNA (MP/RNA complex) - Active state

Summary for 6V5B

Entry DOI	10.2210/pdb6v5b/pdb
EMDB information	21051
Descriptor	Ribonuclease 3, Microprocessor complex subunit DGCR8, Pri-miR-16-2 (78-MER), ... (5 entities in total)
Functional Keywords	microprocessor, drosha, dgcr8, primary microrna, rna binding protein, rna binding protein-rna complex, rna binding protein/rna
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	273298.76
Authors	Partin, A.,Zhang, K.,Jeong, B.,Herrell, E.,Li, S.,Chiu, W.,Nam, Y. (deposition date: 2019-12-04, release date: 2020-04-08, Last modification date: 2024-03-06)
Primary citation	Partin, A.C.,Zhang, K.,Jeong, B.C.,Herrell, E.,Li, S.,Chiu, W.,Nam, Y. Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA. Mol.Cell, 78:411-, 2020 Cited by PubMed: 32220646 DOI: 10.1016/j.molcel.2020.02.016 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.7 Å)

Structure validation