6V34

Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580

Summary for 6V34

• Entry DOI: 10.2210/pdb6v34/pdb
• Descriptor: Serine/threonine-protein kinase B-raf, 6-amino-5-chloro-N-[(1R)-1-(5-{[5-chloro-4-(trifluoromethyl)pyridin-2-yl]carbamoyl}-1,3-thiazol-2-yl)ethyl]pyrimidine-4-carboxamide (2 entities in total)
• Functional Keywords: braf, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 65101.91

Authors

Gonzalez Del-Pino, G.,Li, K.,Eck, M.J. (deposition date: 2019-11-25, release date: 2020-12-02, Last modification date: 2023-10-11)

• Primary citation: Gonzalez Del-Pino, G.,Li, K.,Eck, M.J.; Crystal structure of BRAF V600E oncogenic mutant in complex with TAK-580; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.15 Å)