6UY3

Structure of anti-hCD33 conditional scFv with methotrexate

Summary for 6UY3

Entry DOI	10.2210/pdb6uy3/pdb
Related	3F12 6uup
Descriptor	Anti-CD33 conditional scFv, PHOSPHATE ION, GLYCEROL, ... (5 entities in total)
Functional Keywords	conditional car, mtx, cd33, conditional antibody, antitumor protein
Biological source	Camelidae mixed library
Total number of polymer chains	1
Total formula weight	29364.86
Authors	Kimberlin, C.R.,Park, S. (deposition date: 2019-11-11, release date: 2020-11-18, Last modification date: 2023-10-11)
Primary citation	Park, S.,Pascua, E.,Lindquist, K.C.,Kimberlin, C.,Deng, X.,Mak, Y.S.L.,Melton, Z.,Johnson, T.O.,Lin, R.,Boldajipour, B.,Abraham, R.T.,Pons, J.,Sasu, B.J.,Van Blarcom, T.J.,Chaparro-Riggers, J. Direct control of CAR T cells through small molecule-regulated antibodies. Nat Commun, 12:710-710, 2021 Cited by PubMed: 33514714 DOI: 10.1038/s41467-020-20671-6 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation