6UWR

Clostridium difficile binary toxin translocase CDTb in asymmetric tetradecamer conformation

Summary for 6UWR

Entry DOI	10.2210/pdb6uwr/pdb
EMDB information	20926
Descriptor	ADP-ribosyltransferase binding component, CALCIUM ION (2 entities in total)
Functional Keywords	translocase, binary toxin, toxin
Biological source	Clostridioides difficile
Total number of polymer chains	14
Total formula weight	1047190.48
Authors	Xu, X.,Pozharski, E.,des Georges, A. (deposition date: 2019-11-05, release date: 2020-01-22, Last modification date: 2024-03-06)
Primary citation	Xu, X.,Godoy-Ruiz, R.,Adipietro, K.A.,Peralta, C.,Ben-Hail, D.,Varney, K.M.,Cook, M.E.,Roth, B.M.,Wilder, P.T.,Cleveland, T.,Grishaev, A.,Neu, H.M.,Michel, S.L.J.,Yu, W.,Beckett, D.,Rustandi, R.R.,Lancaster, C.,Loughney, J.W.,Kristopeit, A.,Christanti, S.,Olson, J.W.,MacKerell, A.D.,Georges, A.D.,Pozharski, E.,Weber, D.J. Structure of the cell-binding component of theClostridium difficilebinary toxin reveals a di-heptamer macromolecular assembly. Proc.Natl.Acad.Sci.USA, 117:1049-1058, 2020 Cited by PubMed: 31896582 DOI: 10.1073/pnas.1919490117 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.8 Å)

Structure validation