6UMW

Crystal structure of hEphB1 bound with chlortetracycline

Summary for 6UMW

Entry DOI	10.2210/pdb6umw/pdb
Descriptor	Ephrin type-B receptor 1, 7-CHLOROTETRACYCLINE (3 entities in total)
Functional Keywords	hephb1, chlortetracycline, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	34848.06
Authors	Ahmed, M.,Wang, P.,Sadek, H. (deposition date: 2019-10-10, release date: 2020-10-14, Last modification date: 2023-11-15)
Primary citation	Ahmed, M.S.,Wang, P.,Nguyen, N.U.N.,Nakada, Y.,Menendez-Montes, I.,Ismail, M.,Bachoo, R.,Henkemeyer, M.,Sadek, H.A.,Kandil, E.S. Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain. Proc.Natl.Acad.Sci.USA, 118:-, 2021 Cited by PubMed: 33627480 DOI: 10.1073/pnas.2016265118 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.982 Å)

Structure validation