6UIN

Role of Beta-hairpin motifs in the DNA duplex opening by the Rad4/XPC nucleotide excision repair complex

Summary for 6UIN

• Entry DOI: 10.2210/pdb6uin/pdb
• Descriptor: DNA repair protein RAD4, UV excision repair protein RAD23, DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*(G47)P*AP*CP*AP*TP*CP*CP*CP*CP*CP*CP*CP*TP*AP*CP*AP*A)-3'), ... (4 entities in total)
• Functional Keywords: dna damage recognition, dna damage repair, nucleotide excision repair, beta-hairpin motif, xeroderma pigmentosum, xpc, rad4, molecular dynamics simulations, dna binding protein-dna complex, dna binding protein/dna
• Biological source: Saccharomyces cerevisiae (Baker's yeast); More
• Total number of polymer chains: 4
• Total formula weight: 94610.99

Authors

Paul, D.,Min, J.-H. (deposition date: 2019-10-01, release date: 2020-10-14, Last modification date: 2023-10-11)

• Primary citation: Paul, D.,Mu, H.,Tavakoli, A.,Dai, Q.,Chen, X.,Chakraborty, S.,He, C.,Ansari, A.,Broyde, S.,Min, J.H.; Tethering-facilitated DNA 'opening' and complementary roles of beta-hairpin motifs in the Rad4/XPC DNA damage sensor protein; Nucleic Acids Res., 48:12348-12364, 2021; DOI: 10.1093/nar/gkaa909

Experimental method

X-RAY DIFFRACTION (3.348 Å)