6U8D
Crystal structure of hepatitis C virus IRES junction IIIabc in complex with Fab HCV2
Summary for 6U8D
| Entry DOI | 10.2210/pdb6u8d/pdb |
| Descriptor | JIIIabc RNA (68-MER), Heavy chain of Fab HCV2, Light chain of Fab HCV2, ... (4 entities in total) |
| Functional Keywords | internal ribosome entry site (ires), hepatitis c virus, junction iiiabc, antibody-assisted rna crystallography, viral translation, viral rna domains, rna, rna-immune system complex, rna/immune system |
| Biological source | Homo sapiens (Human) More |
| Total number of polymer chains | 3 |
| Total formula weight | 70444.93 |
| Authors | Koirala, D.,Lewicka, A.,Koldobskaya, Y.,Huang, H.,Piccirilli, J.A. (deposition date: 2019-09-04, release date: 2019-12-04, Last modification date: 2023-10-11) |
| Primary citation | Koirala, D.,Lewicka, A.,Koldobskaya, Y.,Huang, H.,Piccirilli, J.A. Synthetic Antibody Binding to a Preorganized RNA Domain of Hepatitis C Virus Internal Ribosome Entry Site Inhibits Translation. Acs Chem.Biol., 15:205-216, 2020 Cited by PubMed: 31765566DOI: 10.1021/acschembio.9b00785 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.807 Å) |
Structure validation
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