6TY1

Crystal structure of the haemagglutinin mutant (Gln226Leu, Gly228Ser) from an H10N7 seal influenza virus isolated in Germany in complex with human receptor analogue 6'-SLN

Summary for 6TY1

• Entry DOI: 10.2210/pdb6ty1/pdb
• Related PRD ID: PRD_900046
• Descriptor: Hemagglutinin, Hemagglutinin HA2, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• Functional Keywords: receptor binding, fusion of virus membrane with host plasma membrane, viral protein
• Biological source: Influenza A virus (A/harbour seal/Germany/1/2014(H10N7)); More
• Total number of polymer chains: 12
• Total formula weight: 339424.18

Authors

Zhang, J.,Xiong, X.,Purkiss, A.,Walker, P.,Gamblin, S.,Skehel, J.J. (deposition date: 2020-01-15, release date: 2020-10-21, Last modification date: 2024-01-24)

• Primary citation: Herfst, S.,Zhang, J.,Richard, M.,McBride, R.,Lexmond, P.,Bestebroer, T.M.,Spronken, M.I.J.,de Meulder, D.,van den Brand, J.M.,Rosu, M.E.,Martin, S.R.,Gamblin, S.J.,Xiong, X.,Peng, W.,Bodewes, R.,van der Vries, E.,Osterhaus, A.D.M.E.,Paulson, J.C.,Skehel, J.J.,Fouchier, R.A.M.; Hemagglutinin Traits Determine Transmission of Avian A/H10N7 Influenza Virus between Mammals.; Cell Host Microbe, 28:602-613.e7, 2020; PubMed: 33031770; DOI: 10.1016/j.chom.2020.08.011

Experimental method

X-RAY DIFFRACTION (3.2 Å)