6TMC

VIM-2_1dh-Triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases

Summary for 6TMC

Entry DOI	10.2210/pdb6tmc/pdb
Descriptor	Beta-lactamase class B VIM-2, 4-[2-(phenylsulfonyl)ethyl]-5-(propan-2-yloxymethyl)-1~{H}-1,2,3-triazole, ZINC ION, ... (6 entities in total)
Functional Keywords	metallo-beta-lactamase inhibitor, nh-triazole, inhibition properties, crystal structure., antibiotic
Biological source	Pseudomonas aeruginosa
Total number of polymer chains	1
Total formula weight	28936.95
Authors	Leiros, H.-K.S.,Christopeit, T. (deposition date: 2019-12-04, release date: 2020-07-22, Last modification date: 2024-01-24)
Primary citation	Muhammad, Z.,Skagseth, S.,Boomgaren, M.,Akhter, S.,Frohlich, C.,Ismael, A.,Christopeit, T.,Bayer, A.,Leiros, H.S. Structural studies of triazole inhibitors with promising inhibitor effects against antibiotic resistance metallo-beta-lactamases. Bioorg.Med.Chem., 28:115598-115598, 2020 Cited by PubMed: 32631568 DOI: 10.1016/j.bmc.2020.115598 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation