6THO

Acylintermediate of glutathione and the mature primitive phytochelatin synthase Alr0975 from Nostoc PCC 7120 at atomic resolution.

Summary for 6THO

Entry DOI	10.2210/pdb6tho/pdb
Descriptor	Alr0975 protein, OXIDIZED GLUTATHIONE DISULFIDE, CALCIUM ION, ... (4 entities in total)
Functional Keywords	glutathione, phytochelatin, detoxification, chelating heavy atoms, transferase
Biological source	Nostoc sp. PCC 7120
Total number of polymer chains	2
Total formula weight	51520.37
Authors	Feiler, C.G.,Blankenfeldt, W. (deposition date: 2019-11-20, release date: 2020-12-02, Last modification date: 2024-01-24)
Primary citation	Gisdon, F.J.,Feiler, C.G.,Kempf, O.,Foerster, J.M.,Haiss, J.,Blankenfeldt, W.,Ullmann, G.M.,Bombarda, E. Structural and Biophysical Analysis of the Phytochelatin-Synthase-Like Enzyme from Nostoc sp. Shows That Its Protease Activity is Sensitive to the Redox State of the Substrate. Acs Chem.Biol., 17:883-897, 2022 Cited by PubMed: 35377603 DOI: 10.1021/acschembio.1c00941 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.09 Å)

Structure validation