6TDE

Tubulin-inhibitor complex

Summary for 6TDE

Entry DOI	10.2210/pdb6tde/pdb
Descriptor	Tubulin alpha chain, Tubulin beta chain, Stathmin-4, ... (9 entities in total)
Functional Keywords	cytoskeleton, cell division, intracellular transport, cell cycle
Biological source	Rattus norvegicus (Norway rat) More
Total number of polymer chains	5
Total formula weight	220791.47
Authors	Varela, P.F.,Gigant, B. (deposition date: 2019-11-08, release date: 2020-09-02, Last modification date: 2024-01-24)
Primary citation	Shchegravina, E.S.,Svirshchevskaya, E.V.,Combes, S.,Allegro, D.,Barbier, P.,Gigant, B.,Varela, P.F.,Gavryushin, A.E.,Kobanova, D.A.,Shchekotikhin, A.E.,Fedorov, A.Y. Discovery of dihydrofuranoallocolchicinoids - Highly potent antimitotic agents with low acute toxicity. Eur.J.Med.Chem., 207:112724-112724, 2020 Cited by PubMed: 32827941 DOI: 10.1016/j.ejmech.2020.112724 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.286 Å)

Structure validation