6TCA

Phosphorylated p38 and MAPKAPK2 complex with inhibitor

Summary for 6TCA

• Entry DOI: 10.2210/pdb6tca/pdb
• Descriptor: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide (3 entities in total)
• Functional Keywords: mapk, mapkapk, phosphorylated, p38, mk2, signaling protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 8
• Total formula weight: 340485.94

Authors

Sok, P.,Remenyi, A. (deposition date: 2019-11-05, release date: 2020-07-22, Last modification date: 2024-01-24)

• Primary citation: Sok, P.,Gogl, G.,Kumar, G.S.,Alexa, A.,Singh, N.,Kirsch, K.,Sebo, A.,Drahos, L.,Gaspari, Z.,Peti, W.,Remenyi, A.; MAP Kinase-Mediated Activation of RSK1 and MK2 Substrate Kinases.; Structure, 28:1101-1113.e5, 2020; PubMed: 32649858; DOI: 10.1016/j.str.2020.06.007

Experimental method

X-RAY DIFFRACTION (3.7 Å)