6T9D

Crystal structure of a bispecific DutaFab in complex with human VEGF121

This is a non-PDB format compatible entry.

Summary for 6T9D

• Entry DOI: 10.2210/pdb6t9d/pdb
• Descriptor: VP mat DutaFab VH chain, VP mat DutaFab VL chain, Vascular endothelial growth factor A, ... (4 entities in total)
• Functional Keywords: monoclonal antibody, bispecific antibody, fab fragment, vegf, immune system
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 6
• Total formula weight: 122801.39

Authors

Kimbung, R.,Logan, D.T.,Beckmann, R.,Jensen, K.,Speck, J.,Fenn, S.,Kettenberger, H. (deposition date: 2019-10-28, release date: 2020-12-16, Last modification date: 2024-01-24)

• Primary citation: Beckmann, R.,Jensen, K.,Fenn, S.,Speck, J.,Krause, K.,Meier, A.,Roth, M.,Fauser, S.,Kimbung, R.,Logan, D.T.,Steegmaier, M.,Kettenberger, H.; DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously.; Nat Commun, 12:708-708, 2021; PubMed: 33514724; DOI: 10.1038/s41467-021-20949-3

Experimental method

X-RAY DIFFRACTION (2.905 Å)