6T5Q

Human Carbonic anhydrase XII bound by 3,5-diphenylbenzenesulfonamide

Summary for 6T5Q

• Entry DOI: 10.2210/pdb6t5q/pdb
• Related: 6T4N 6T4O 6T4P 6T5C 6T5P
• Descriptor: Carbonic anhydrase 12, ZINC ION, 3,5-diphenylbenzenesulfonamide, ... (5 entities in total)
• Functional Keywords: drug design, carbonic anhydrase, benzenesulfonamide, metal-binding, lyase-lyase inhibitor complex, lyase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 120983.19

Authors

Smirnov, A.,Manakova, E.,Grazulis, S. (deposition date: 2019-10-16, release date: 2020-10-14, Last modification date: 2024-01-24)

• Primary citation: Dudutiene, V.,Zubriene, A.,Kairys, V.,Smirnov, A.,Smirnoviene, J.,Leitans, J.,Kazaks, A.,Tars, K.,Manakova, L.,Grazulis, S.,Matulis, D.; Isoform-Selective Enzyme Inhibitors by Exploring Pocket Size According to the Lock-and-Key Principle.; Biophys.J., 119:1513-1524, 2020; PubMed: 32971003; DOI: 10.1016/j.bpj.2020.08.037

Experimental method

X-RAY DIFFRACTION (1.8 Å)