6T5I

The Transcriptional Regulator PrfA from Listeria Monocytogenes in complex with inhibitor of WNT production (IWP)-2

Summary for 6T5I

• Entry DOI: 10.2210/pdb6t5i/pdb
• Descriptor: Listeriolysin positive regulatory factor A, ~{N}-(6-methyl-1,3-benzothiazol-2-yl)-2-[(4-oxidanylidene-3-phenyl-6,7-dihydrothieno[3,2-d]pyrimidin-2-yl)sulfanyl]ethanamide, DIMETHYL SULFOXIDE, ... (5 entities in total)
• Functional Keywords: listeria monocytogenes, transcription, dna binding protein, inhibitor of wnt (iwp)
• Biological source: Listeria monocytogenes
• Total number of polymer chains: 2
• Total formula weight: 56287.08

Authors

Oelker, M.,Grundstrom, C.,Blumenthal, A.,Sauer-Eriksson, A.E. (deposition date: 2019-10-16, release date: 2021-10-27, Last modification date: 2024-01-24)

• Primary citation: Tran, T.T.,Mathmann, C.D.,Gatica-Andrades, M.,Rollo, R.F.,Oelker, M.,Ljungberg, J.K.,Nguyen, T.T.K.,Zamoshnikova, A.,Kummari, L.K.,Wyer, O.J.K.,Irvine, K.M.,Melo-Bolivar, J.,Gross, A.,Brown, D.,Mak, J.Y.W.,Fairlie, D.P.,Hansford, K.A.,Cooper, M.A.,Giri, R.,Schreiber, V.,Joseph, S.R.,Simpson, F.,Barnett, T.C.,Johansson, J.,Dankers, W.,Harris, J.,Wells, T.J.,Kapetanovic, R.,Sweet, M.J.,Latomanski, E.A.,Newton, H.J.,Guerillot, R.J.R.,Hachani, A.,Stinear, T.P.,Ong, S.Y.,Chandran, Y.,Hartland, E.L.,Kobe, B.,Stow, J.L.,Sauer-Eriksson, A.E.,Begun, J.,Kling, J.C.,Blumenthal, A.; Inhibition of the master regulator of Listeria monocytogenes virulence enables bacterial clearance from spacious replication vacuoles in infected macrophages.; Plos Pathog., 18:e1010166-e1010166, 2022; PubMed: 35007292; DOI: 10.1371/journal.ppat.1010166

Experimental method

X-RAY DIFFRACTION (2 Å)