6SYW
human Aldose Reductase in complex with SAR25
Summary for 6SYW
Entry DOI | 10.2210/pdb6syw/pdb |
Related | 4QBX 4YS1 |
Descriptor | aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, CITRIC ACID, ... (5 entities in total) |
Functional Keywords | diabetes, oxidoreductase, transient binding pocket, diabetic late effects, polyol pathway, osmotic and oxidative stress, cofactor, nadph, nadp+, akr1b1, aldr1, alr2 |
Biological source | Homo sapiens |
Total number of polymer chains | 1 |
Total formula weight | 37101.12 |
Authors | Sandner, A.,Heine, A.,Klebe, G. (deposition date: 2019-10-01, release date: 2020-10-14, Last modification date: 2024-01-24) |
Primary citation | Sandner, A.,Heine, A.,Klebe, G.,Diederich, W.,Scheer, F.M. human Aldose Reductase in complex with SAR25 To Be Published, |
Experimental method | X-RAY DIFFRACTION (0.93 Å) |
Structure validation
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