6SSZ
Structure of the Plasmodium falciparum falcipain 2 protease in complex with an (E)-chalcone inhibitor.
Summary for 6SSZ
| Entry DOI | 10.2210/pdb6ssz/pdb |
| Descriptor | Cysteine proteinase falcipain 2a, (~{E})-3-(1,3-benzodioxol-5-yl)-1-(3-nitrophenyl)prop-2-en-1-one (2 entities in total) |
| Functional Keywords | inhibitor, complex, malaria, haemoglobin, proteolysis, hydrolase |
| Biological source | Plasmodium falciparum |
| Total number of polymer chains | 2 |
| Total formula weight | 54953.84 |
| Authors | Machin, J.,Kantsadi, A.,Vakonakis, I. (deposition date: 2019-09-09, release date: 2019-12-04, Last modification date: 2024-01-24) |
| Primary citation | Machin, J.M.,Kantsadi, A.L.,Vakonakis, I. The complex of Plasmodium falciparum falcipain-2 protease with an (E)-chalcone-based inhibitor highlights a novel, small, molecule-binding site. Malar.J., 18:388-388, 2019 Cited by PubMed: 31791339DOI: 10.1186/s12936-019-3043-0 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (3.45 Å) |
Structure validation
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