6SNN
Crystal structure of cAMP-dependent protein kinase A (CHO PKA) in complex with benzoic acid
Summary for 6SNN
Entry DOI | 10.2210/pdb6snn/pdb |
Descriptor | cAMP-dependent protein kinase catalytic subunit alpha, BENZOIC ACID (3 entities in total) |
Functional Keywords | phosphotransferase, signalling pathways, glycogen metabolism, serine/threonine kinase, transferase |
Biological source | Cricetulus griseus (Chinese hamster) |
Total number of polymer chains | 1 |
Total formula weight | 41162.81 |
Authors | Oebbeke, M.,Merkl, S.,Siefker, C.,Heine, A.,Klebe, G. (deposition date: 2019-08-27, release date: 2020-09-09, Last modification date: 2020-12-30) |
Primary citation | Oebbeke, M.,Siefker, C.,Wagner, B.,Heine, A.,Klebe, G. Fragment Binding to Kinase Hinge: If Charge Distribution and Local pK a Shifts Mislead Popular Bioisosterism Concepts. Angew.Chem.Int.Ed.Engl., 60:252-258, 2021 Cited by PubMed: 33021032DOI: 10.1002/anie.202011295 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.817 Å) |
Structure validation
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