6SIQ

Fragment AZ-012 binding at the p53pT387/14-3-3 sigma interface

Summary for 6SIQ

Entry DOI	10.2210/pdb6siq/pdb
Related	6sip
Descriptor	14-3-3 protein sigma, Cellular tumor antigen p53, CHLORIDE ION, ... (5 entities in total)
Functional Keywords	protein protein interaction, fragment soaking, stabilization, peptide binding protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28565.41
Authors	Leysen, S.,Wolter, M.,Guillory, X.,Genet, S.,Somsen, B.,Patel, J.,Castaldi, P.,Ottmann, C. (deposition date: 2019-08-10, release date: 2020-06-17, Last modification date: 2024-01-24)
Primary citation	Guillory, X.,Wolter, M.,Leysen, S.,Neves, J.F.,Kuusk, A.,Genet, S.,Somsen, B.,Morrow, J.K.,Rivers, E.,van Beek, L.,Patel, J.,Goodnow, R.,Schoenherr, H.,Fuller, N.,Cao, Q.,Doveston, R.G.,Brunsveld, L.,Arkin, M.R.,Castaldi, P.,Boyd, H.,Landrieu, I.,Chen, H.,Ottmann, C. Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63:6694-6707, 2020 Cited by PubMed: 32501690 DOI: 10.1021/acs.jmedchem.9b01942 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.60121 Å)

Structure validation