6SGH
Nek2 kinase covalently bound to 2-arylamino-6-ethynylpurine inhibitor 66
Summary for 6SGH
Entry DOI | 10.2210/pdb6sgh/pdb |
Descriptor | Serine/threonine-protein kinase Nek2, 2-[4-[(6-ethenyl-9~{H}-purin-2-yl)amino]phenyl]ethanamide (3 entities in total) |
Functional Keywords | "covalent inhibitor" kinase, cell cycle |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 32956.79 |
Authors | Richards, M.W.,Mas-Droux, C.P.,Bayliss, R. (deposition date: 2019-08-04, release date: 2020-06-17, Last modification date: 2024-01-24) |
Primary citation | Matheson, C.J.,Coxon, C.R.,Bayliss, R.,Boxall, K.,Carbain, B.,Fry, A.M.,Hardcastle, I.R.,Harnor, S.J.,Mas-Droux, C.,Newell, D.R.,Richards, M.W.,Sivaprakasam, M.,Turner, D.,Griffin, R.J.,Golding, B.T.,Cano, C. 2-Arylamino-6-ethynylpurines are cysteine-targeting irreversible inhibitors of Nek2 kinase. Rsc Med Chem, 11:707-731, 2020 Cited by PubMed: 33479670DOI: 10.1039/d0md00074d PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3 Å) |
Structure validation
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