6S8V

Structure of the high affinity Anticalin P3D11 in complex with the human CD98 heavy chain ectodomain

Summary for 6S8V

Entry DOI	10.2210/pdb6s8v/pdb
Descriptor	Neutrophil gelatinase-associated lipocalin, 4F2 cell-surface antigen heavy chain, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	lipocalin, lcn2, anticalin, lipocalin-based binding protein, cd98hc, 4f2hc, amino acid transport, presentation of cd98 light chains, interaction with integrin beta subunits, single-pass type ii membrane protein, protein binding
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	137420.47
Authors	Schiefner, A.,Deuschle, F.-C.,Skerra, A. (deposition date: 2019-07-10, release date: 2020-03-04, Last modification date: 2024-01-24)
Primary citation	Deuschle, F.C.,Morath, V.,Schiefner, A.,Brandt, C.,Ballke, S.,Reder, S.,Steiger, K.,Schwaiger, M.,Weber, W.,Skerra, A. Development of a high affinity Anticalin®directed against human CD98hc for theranostic applications. Theranostics, 10:2172-2187, 2020 Cited by PubMed: 32089738 DOI: 10.7150/thno.38968 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation