6S5K

LXRbeta ligand binding domain in complex with small molecule inhibitors

Summary for 6S5K

Entry DOI	10.2210/pdb6s5k/pdb
Descriptor	Oxysterols receptor LXR-beta, 3-(4-phenylbutylamino)-1,4-bis(phenylmethyl)pyrrole-2,5-dione (3 entities in total)
Functional Keywords	liver x receptor beta, lxrb, lxr beta, nuclear hormone receptor, receptor ligand binding domain, nuclear protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	28696.02
Authors	Petersen, J. (deposition date: 2019-07-01, release date: 2019-12-18)
Primary citation	Belorusova, A.Y.,Evertsson, E.,Hovdal, D.,Sandmark, J.,Bratt, E.,Maxvall, I.,Schulman, I.G.,Akerblad, P.,Lindstedt, E.L. Structural analysis identifies an escape route from the adverse lipogenic effects of liver X receptor ligands. Commun Biol, 2:431-431, 2019 Cited by PubMed: 31799433 DOI: 10.1038/s42003-019-0675-0 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation