6RMV

The crystal structure of a TRP channel peptide bound to a G protein beta gamma heterodimer

Summary for 6RMV

Entry DOI	10.2210/pdb6rmv/pdb
Descriptor	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Transient receptor potential cation channel, subfamily M, member 3, ... (5 entities in total)
Functional Keywords	g protein, trp channel, inhibitor, protein binding
Biological source	Mus musculus (Mouse) More
Total number of polymer chains	3
Total formula weight	47286.39
Authors	Gruss, F.,Oberwinkler, J.,Ulens, C. (deposition date: 2019-05-07, release date: 2020-10-14, Last modification date: 2024-01-24)
Primary citation	Behrendt, M.,Gruss, F.,Enzeroth, R.,Dembla, S.,Zhao, S.,Crassous, P.A.,Mohr, F.,Nys, M.,Louros, N.,Gallardo, R.,Zorzini, V.,Wagner, D.,Economou, A.,Rousseau, F.,Schymkowitz, J.,Philipp, S.E.,Rohacs, T.,Ulens, C.,Oberwinkler, J. The structural basis for an on-off switch controlling G beta gamma-mediated inhibition of TRPM3 channels. Proc.Natl.Acad.Sci.USA, 117:29090-29100, 2020 Cited by PubMed: 33122432 DOI: 10.1073/pnas.2001177117 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation