6RKQ

Crystal Structure of TGT in complex with N2-methyl-8-(prop-1-yn-1-yl)-3H,7H,8H-imidazo[4,5-g]quinazoline-2,6-diamine

Summary for 6RKQ

Entry DOI	10.2210/pdb6rkq/pdb
Descriptor	Queuine tRNA-ribosyltransferase, ZINC ION, (8~{R})-~{N}2-methyl-8-prop-1-ynyl-7,8-dihydro-3~{H}-imidazo[4,5-g]quinazoline-2,6-diamine, ... (6 entities in total)
Functional Keywords	tgt, trna, guanine exchange enzyme, protein interface, transferase, transglycosylase
Biological source	Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4)
Total number of polymer chains	1
Total formula weight	42253.41
Authors	Hassaan, E.,Heine, A.,Klebe, G. (deposition date: 2019-04-30, release date: 2020-06-03, Last modification date: 2024-01-24)
Primary citation	Hassaan, E.,Hohn, C.,Ehrmann, F.R.,Goetzke, F.W.,Movsisyan, L.,Hufner-Wulsdorf, T.,Sebastiani, M.,Hartsch, A.,Reuter, K.,Diederich, F.,Klebe, G. Fragment Screening Hit Draws Attention to a Novel Transient Pocket Adjacent to the Recognition Site of the tRNA-Modifying Enzyme TGT. J.Med.Chem., 63:6802-6820, 2020 Cited by PubMed: 32515955 DOI: 10.1021/acs.jmedchem.0c00115 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.665 Å)

Structure validation