6R6U

Crystal structure of human cis-aconitate decarboxylase

Summary for 6R6U

Entry DOI	10.2210/pdb6r6u/pdb
Descriptor	Cis-aconitate decarboxylase, (R,R)-2,3-BUTANEDIOL, SODIUM ION, ... (4 entities in total)
Functional Keywords	immunity, inflammatory response, innate immunity, antimicrobial, decarboxylase, cis-aconitate, itaconate, lyase
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	101880.06
Authors	Lukat, P.,Chen, F.,Saile, K.,Buessow, K.,Pessler, F.,Blankenfeldt, W. (deposition date: 2019-03-28, release date: 2019-09-25, Last modification date: 2024-01-24)
Primary citation	Chen, F.,Lukat, P.,Iqbal, A.A.,Saile, K.,Kaever, V.,van den Heuvel, J.,Blankenfeldt, W.,Bussow, K.,Pessler, F. Crystal structure ofcis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc.Natl.Acad.Sci.USA, 116:20644-20654, 2019 Cited by PubMed: 31548418 DOI: 10.1073/pnas.1908770116 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.705 Å)

Structure validation