6R2D

Crystal structure of the SucA domain of Mycobacterium smegmatis KGD after soaking with succinylphosphonate phosphonoethyl ester, followed by temperature increase

Summary for 6R2D

Entry DOI	10.2210/pdb6r2d/pdb
Descriptor	Multifunctional 2-oxoglutarate metabolism enzyme, (4~{S})-4-[(2~{R})-3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-2~{H}-1,3-thiazol-2-yl]-4-[ethoxy(oxidanyl)phosphoryl]-4-oxidanyl-butanoic acid, MAGNESIUM ION, ... (5 entities in total)
Functional Keywords	oxoglutarate dehydrogenase, tpp-dependent decarboxylase, oxidoreductase
Biological source	Mycobacterium smegmatis (strain ATCC 700084 / mc(2)155)
Total number of polymer chains	4
Total formula weight	391469.90
Authors	Wagner, T.,Alzari, P.M.,Bellinzoni, M. (deposition date: 2019-03-15, release date: 2019-09-11, Last modification date: 2024-01-24)
Primary citation	Wagner, T.,Boyko, A.,Alzari, P.M.,Bunik, V.I.,Bellinzoni, M. Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: From a Michaelis-like complex to ThDP adducts. J.Struct.Biol., 208:182-190, 2019 Cited by PubMed: 31476368 DOI: 10.1016/j.jsb.2019.08.012 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation