6R0K

X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS208

Summary for 6R0K

Entry DOI	10.2210/pdb6r0k/pdb
Descriptor	Histone deacetylase 6, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	protein deacetylase, histone deacetylase 6, zinc-binding, isoxazole-3-hydroxamate analogues, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	1
Total formula weight	40851.54
Authors	Barinka, C.,Ustinova, K.,Motlova, L.,Pavlicek, J. (deposition date: 2019-03-13, release date: 2019-10-09, Last modification date: 2024-01-24)
Primary citation	Shen, S.,Hadley, M.,Ustinova, K.,Pavlicek, J.,Knox, T.,Noonepalle, S.,Tavares, M.T.,Zimprich, C.A.,Zhang, G.,Robers, M.B.,Barinka, C.,Kozikowski, A.P.,Villagra, A. Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J.Med.Chem., 62:8557-8577, 2019 Cited by PubMed: 31414801 DOI: 10.1021/acs.jmedchem.9b00946 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.15 Å)

Structure validation