6QZR

14-3-3 sigma in complex with FOXO1 pT24 peptide

Summary for 6QZR

• Entry DOI: 10.2210/pdb6qzr/pdb
• Related: 6qzs
• Descriptor: 14-3-3 protein sigma, Forkhead box protein O1, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (5 entities in total)
• Functional Keywords: protein binding, 14-3-3, foxo1, peptide binding protein
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 16
• Total formula weight: 239199.04

Authors

Ottmann, C.,Wolter, M.,Lau, R.A. (deposition date: 2019-03-12, release date: 2019-07-31, Last modification date: 2024-01-24)

• Primary citation: Saline, M.,Badertscher, L.,Wolter, M.,Lau, R.,Gunnarsson, A.,Jacso, T.,Norris, T.,Ottmann, C.,Snijder, A.; AMPK and AKT protein kinases hierarchically phosphorylate the N-terminus of the FOXO1 transcription factor, modulating interactions with 14-3-3 proteins.; J.Biol.Chem., 294:13106-13116, 2019; PubMed: 31308176; DOI: 10.1074/jbc.RA119.008649

Experimental method

X-RAY DIFFRACTION (2.3 Å)